PROBIOTICS ROLE IN LOWERING BILIRUBIN LEVEL ON HYPERBILIRUBINEMIA NEONATES PERFORMED PHOTOTHERAPY AT NEONATOLOGY WARD OF ADAM MALIK GENERAL HOSPITAL.

Abstract

Background : Hyperbilirubinemia is found in approximately 60% on full term infants hospitalized during their first week of life. The most widely used therapy in neonates with hyperbilirubinemia is phototherapy. Probiotics can accelerate the decrease in bilirubin levels by stimulating the peristaltics of the gastrointestinal tract, thus, increasing the amount of bilirubin being eliminated.

Objective : to proves whether probiotics has a role in helping to speed up the reduction of bilirubin levels in neonates with hyperbilirubinemia who are having phototherapy..

Method : A Cross-sectional study was conducted on full term neonates(38 - 42 weeks) in neonatology room at Adam Malik General Hospital, Medan, North Sumatera. The participants were grouped into 2 groups, one received probiotics and the other did not. Each group was evaluated on both total bilirubin serum and total direct bilirubin serum rates. The result data were analyzed using Anova and independent sample test.

Result : From 39 aterm neonates with hyperbilirubinemia. 3 samples were excluded. Out of these 36, 17 are boys (47.2 %)and 19 are girls (52.8%). The results showed a greater decrease in total bilirubin levels of prticipants in probiotic groups than those who are in non-probiotic groups. Anova test with P value = 0.0001 Anova test with P value = 0.0001

Conclusion : The mean decrease in total bilirubin levels was greater in the probiotic groups than non-probiotic groups among full-term neonates with hyperbilirubinemia.