ASSOCIATION OF NON CHOLESTEROL HIGH DENSITY LIPOPROTEIN-TO-TOTAL CHOLESTEROL RATIO WITH SEVERITY OF CORONARY ARTERY LESION USING SYNTAX SCORE IN PATIENTS WITH ACUTE CORONARY SYNDROMES
Keywords:
Atherosclerosis, Acute Coronary Syndrome, Non-HDL/TC Ratio, SYNTAX ScoreAbstract
Background: Coronary Artery disease (CAD) is still the leading cause of morbidity and mortality in the world. Many studies centered on the diagnosis or prognosis of CAD suggested dyslipidemia might be associated with severity of atherosclerosis. The ratio of non-HDL cholesterol to total cholesterol (non-HDL-c/TC) is a prognostic marker that combines 2 variables into one. The SYNTAX score is an anatomic scoring system based on coronary artery angiography (CAG) to quantify severity and complexity coronary lesion. The aim of this study was to investigate the association of the non-HDL-c/TC ratio with coronary artery severity using the SYNTAX score in patients with acute coronary syndrome (ACS) who underwent coronary artery angiography.
Methods: Patients were recruited from June to December 2019. This cross-sectional study involved 71 patients who were admitted from the emergency department. Variables such as comorbidities, coronary artery angiography and laboratory finding were evaluated. The non-HDL-c was calculated as total cholesterol (TC) minus HDL-c, while non- HDL-c/TC was the ratio of non-HDL-c and TC. Coronary artery angiography was performed, and the SYNTAX score was calculated in all the subjects divided into two subgroups, those with low SYNTAX score (≤22) and those with high SYNTAX score (≥23).
Results: a total of 71 patients with ACS who underwent CAG were included in the study from June to December 2019. From total 71 patients, there were 36 patients (50.7%) had a SYNTAX score ≥ 23 and 35 patients (49.3%) had a SYNTAX score ≤ 22. There were significant relation difference between both groups. From pearson's analysis, there was significant statistic between ratio of non-HDL/TC and SYNTAX score (r = 0.299; P value: <0.001).
Conclusion: Non-HDL-c/TC ratio is significantly associated with severity of coronary lesion using SYNTAX score in patients with acute coronary syndrome.
