CORRELATION BETWEEN PROTHROMBIN TIME, ACTIVATED PARTIAL THROMBOPLASTIN TIME AND D – DIMER WITH PROGNOSIS OF ACUTE ISCHEMIC STROKE IN ADAM MALIK HOSPITAL MEDAN
Keywords:
Ischemic stroke, prothrombin time, activated partial thromboplastin time, d – dimer, NIHSS, prognosisAbstract
Background: The state of hypercoagulation is the basis for thrombosis and significant for the occurrence of ischemic stroke. About 80% of ischemic strokes, the basis of which is atherothrombosis in large blood vessels, microateromes in small blood vessels, and emboli from the heart.
Objectives: To determine the relationship between prothrombin time, activated partial thromboplastin time and d-dimer with the prognosis of acute ischemic stroke.
Methods: This study uses a cross sectional design. Sampling was carried out at H. Adam Malik General Hospital Medan. The study sample was taken as many as 40 subjects consecutively. To determine the difference in prothrombin time (PT), activated partial thromboplastin time (APTT) and d-dimer levels and NIHSS scores paired t tests were used if the data were normally distributed and the Wilcoxon test if the data were not normally distributed. And determine the relationship between prothrombin time, activated partial thromboplastin time and d-dimer with NIHSS scores on the first and seventh days the Spearman correlation was used.
Results: Demographic characteristics of the subjects are the average age of 52-<68 years, the level of high school education, the work of housewives and farmers and the Batak tribe. There is no significant relationship between PT firts day and NIHSS score first day and there is no significant relationship between PT seventh day and NIHSS score seventh day. There is no significant relationship between APTT first day and NIHSS first day score and there is no significant relationship between APTT seventh day and NIHSS score seventh day. There is a significant relationship between D-dimer first day and NIHSS first day score and there is a significant relationship between D-dimer seventh day and NIHSS score seventh day.
Conclusions: There is a significant relationship between d-dimer with NIHSS scores on the first day and seventh days in patients with acute ischemic stroke.
