THE EFFECT OF PERCUTANEOUS CORONARY INTERVENTION (PCI) WITH DES ON ANTITHROMBIN-III (AT-III) AND THROMBIN ANTITHROMBIN COMPLEX (TAT) IN CORONARY HEART DISEASE PATIENTS AT HAJI ADAM MALIK GENERAL HOSPITAL

Abstract

Introduction: Percutaneous coronary intervention (PCI) is currently the most commonly used invasive procedure in patients with coronary artery disease (CAD). PCI procedure can cause friction to the endothelium leading to the release and activation of thrombin. Thrombin activation increases the risk of restenosis. This study aims to determine the effect of PCI on AT-III and TAT levels in coronary artery disease (CAD) patients.

Methods: This study was conducted on CAD patients who will undergo PCI and have met the inclusion criteria. Blood samples were collected before and after PCI procedure and were examined for AT-III and TAT measurements. The value obtained is then analyzed based on changes in values before and after the PCI procedure, and is significant if the p-value <0.05.

Results: A total of 20 subjects, 17 males and 3 females. The mean of pre-PCI procedure for AT-III and TAT were 92.4 ± 7.17 and 6.1 ± 1.02 while the mean of post-PCI procedure for AT-III and TAT were 100.7 ± 12.78 and 5.17 ± 1.36, with a significant with the p-value <0.001

Conclusion: There is an increase level of AT-III and a decrease level of TAT in post-PCI CAD patients.