PENTRAXIN-3 LEVELS IN TYPE 2 DM WITH CAD AND TYPE 2 DM WITHOUT CAD

Abstract

Background Coronary artery disease (CAD) is the main cause of death and illness in type 2 DM patients. This is closely related to endothelial damage caused by inflammation, platelet hyperactivity and activation of coagulation factors that trigger an increase in various chemical mediators in the body. Pentraxin-3 (PTX3) is produced by a variety of cells in atherosclerotic lesions, including monocytes and macrophages, endothelial cells, vascular smooth muscle cells, fibroblasts, dendritic cells, and adipocytes.

Aim To see the relationship between pentraxin-3 level with type 2 DM and coronary arterial disease.

Method An analytical observational research with cross-sectional measurement method. A total of 38 subjects with sepsis, were tested for pentraxin 3 serum level then analyzed statistically.

Result Of the 38 patients who were the study sample, 19 type 2 DM patients without CAD had a median pentraxin-3 level of 2.45 ng / mL while 19 other patients who had type 2 DM with CAD median pentraxin-3 levels were 8.68 ng / mL. By using statistical analysis to see the difference between the two it was found p = 0.005.

Conclusion There was a significant difference between the pentraxin-3 levels of type 2 DM patients with CAD and without CAD. Type 2 DM patients with CAD had higher pentraxin-3 levels.