CORRELATION BETWEEN SERUM VITAMIN D LEVELS AND CURB 65 ADMISSION IN PATIENTS WITH COMMUNITY ACQUIRED PNEUMONIA AT THE START OF HOSPITAL

Abstract

Introduction : Pneumonia is still a major cause of morbidity and mortality worldwide.1 World health organization (WHO) predicts there are 429.2 million morbidity and 94.5 million disability figures due to pneumonia.2 Community-acquired pneumonia is the most common and serious type of pneumonia, and become the most common infectious diseases. Community-acquired pneumonia also causes the most deaths and morbidity in the world.1 Pneumonia become one of top 10 hospitalizations in hospitals. CURB-65 (Confusion, Blood urea nitrogen, Respiratory rate, Blood pressure, Age> 65 years) are validated predictors and widely known in determining the degree of pneumonia in various countries. Besides the classic function in maintaining the balance of calcium and phosphate. Vitamin D also has immune modulating properties. Some study have proved the relationship between lack of vitamin D levels in serum with an increase in airway infections.

Aim: To evaluate the correlation between Vitamin D level in serum with CURB-65 value in community acquired pneumonia patients at the start of hospital.

Methods: This study used cross sectional study in 54 patients with community acquired pneumonia at Haji Adam Malik General Hospital, Medan, North Sumatera. Community acquired pneumonia was established through clinical and radiological examination (chest x-ray). CURB-65 uses 5 clinical variables: Confusion, Blood urea nitrogen> 7 mmol / L (> 20 mg / dL), respiratory rate> 30 / minute, systolic blood pressure (<90 mmHg) or diastolic ( <60mmHg), and age> 65 years. Total vitamin D levels in serum was determined by Enzyme-Linked Fluourescent Assay (ELFA) method (MINI VIDAS BRAHMS). . Data were collected and analyzed using SPSS version 23.

Results : 54 patien with community acquired pneumonia,24 people vitamin D ≤ 2 (44,4 %) and 30 people vitamin D> 2 (55,6%). 34 people CURB-65≤ 2 (63%) and 20 people CURB-65 > 2 (37%).There is a significant association between Vitamin D Score CURB 65 with a value of p = 0.020.

Conclusions: There was statistically significant relationship between vitamin D and score CURB-65( p= 0,020) and a negative moderate correlation between vitamin D levels and the CURB-65 score (p = 0.016; r = -0.332)