COMPARISON OF THE EFFECT BAY LEAVES (SYZYGIUMPOLYANTHUM (WIGHT) WALP) WITH A DOSAGE OF 400MG AND 600MG TO HS-CRP IN PATIENTS WITH DYSLIPIDEMIA

Abstract

ntroduction:The use of herbal medicines has long been practiced throughout the world. The potential of the herbal medicine and phytopharmaca market in Indonesia is very large.

Aim: to analyze the comparison of bay leaves with different doses of hs-CRP levels in dyslipidemic patients.

Method: This study is a prospective clinical trial design. Research will begin in August 2017 until February 2018 or until the number of research subjects is fulfilled. Provision and processing of test plants in collaboration with a team of pharmacists in the Laboratory of Traditional Medicine Section, Faculty of Pharmacy, University of North Sumatra. Analytical statistical analysis of the independent T Test or Mann Whitney U is used. Differences were considered statistically significant if the value of p <0.05.

Results : The subjects of the study amounted to 30 people divided into two groups, namely 15 subjects with a dose of 2x200 mg and 15 subjects with a dose of 2x300 mg. In the 2x200 mg dose group there was a significant decrease in mean hs-CRP before treatment compared to after treatment ((3.92 + 3.89vs2.34 + 2.22) mg / dL; p = 0.001; 95% CI). In the 2x300 mg group there was also a decrease in the mean hs-CRP before treatment compared with after treatment, but it was not statistically significant ((4.34 + 3.03 vs 3.45 + 2.88) mg / dL; p = 0.009; IK 95%). The mean reduction in hs-CRP in the 2x300 mg group compared with the 2x200 mg group was greater, statistically significant ((0.93 vs 1.58) mg / dL; p value = 0.005; 95% CI).

Conclusion: Giving salam leaf extract (Syzygiumpolyanthum (Wight) Walp) for 30 days there was a significant difference in the effect of giving bay leaves at different doses of 2x200mg vs. 2x300mg to hs-CRP levels in dyslipidemia patients.