ASSOCIATION BETWEEN LEFT VENTRICULAR DIASTOLIC DYSFUNCTION AND SEVERITY OF CORONARY ARTERY DISEASE IN NSTEMI PATIENTS

Abstract

Background : Myocardial ischemia caused by coronary artery lesion can cause systolic and diastolic dysfunction. Diastolic dysfunction is a result from ineffective left ventricle relaxation. Early identification of extensive ischemia based on diastolic function parameters through echocardiography is very useful. This can provide clinicians with knowledge about the severity of coronary artery lesions so that they can help determine more appropriate treatment strategies.

Methods : A cross-sectional study of NSTEMI patients who underwent coronary angiography were included. LV diastolic dysfunction was assessed by echocardiographic parameters. LV diastolic dysfunction was divided into 3 groups (Grade I, Grade II, and Grade III). Severity of coronary artery lesions were analysed by SYNTAX score, which was further divided into 3 groups (low, moderate, and high SYNTAX score).

Results : A total of 110 patients presented with NSTEMI were included in this study (88 males and 22 females, with mean age 56.9  9.6 years old). Bivariate analysis between SYNTAX scores and baseline characteristics found a significant relationship in age and echocardiographic characteristics such as LVEF, LVEDD, E/A ratio, average E/e’ ratio, TR maximum velocity and LA volume index. On the analysis between LV diastolic dysfunction and SYNTAX score resulted in significant relationship with p value <0.001.