CORRELATION OF TRIGLYCERIDE-GLUCOSE INDEX (TyG) WITH MAJOR CARDIOVASCULAR EVENTS (MACE) DURING TREATMENT IN NON ST ELEVATION (NSTEMI) ACUTE MIOCARD INFARK PATIENTS IN ADAM MALIK GENERAL HOSPITAL MEDAN

Abstract

Background: NSTEMI is caused by partial occlusion of coronary artery induced by ruptured atheromatous plaque. Major Adverse Cardiovascular Events is an advanced clinical event in the cardiovascular system, consisting of cardiovascular death, malignant arrhythmia, cardiogenic shock, and acute heart failure. TyG index is metabolite of fasting glucose and TG which are associated with the occurrence of cardiovascular disease. Objective: to assessed correlation between TyG index and MACE in NSTEMI patients as a prognostic marker for MACE.

Methods: NSTEMI patients who were treated at HAM Hospital Medan in January 2020 were examined for fasting glucose and TG levels, then were observed for MACE during in-hospital treatment. There were two groups includes experiencing MACE and without MACE that classificated into TyG index ≤8.805 and ≥8.805.

Results: From 86 NSTEMI patients, 54 (62.8%) experienced MACE with mean age was 56.52 years old. There was significant relationship between MACE with higher TyG index, GRACE score, fasting glucose, post prandial glucose, history of DM and dyslipidemia. ROC curve analysis showed that TyG index was able to predict the incidence of MACE (cut-off point 9.0021, AUC = 0.646, p<0.024, sensitivity 61.1%, specificity 65.6%).

Conclusion: TyG index can predicts the incidence of MACE in NSTEMI patients.