RELATIONSHIP BETWEEN HIGH DENSITY LIPOPROTEIN (HDL) AND RED CELL DISTRIBUTION WIDTH (RDW) VALUE WITH THE DEGREE OF CORONARY HEART DISEASE

Abstract

Background. Coronary heart disease causes the most deaths in the world. Coronary artery stenosis can be seen with angiography. A high RDW value is associated with the intimal-medial thickness of the atherosclerotic carotid artery. Recently, RDW was found to be a novel independent predictor of prognosis in patients with acute myocardial infarction or congestive heart failure, after percutaneous aortic valve implantation, and among patients with risk factors or coronary artery disease.

Aim. To see the relationship between HDL levels and RDW values with the degree of severity of coronary heart disease associated with this Gensini score, using an analytical observational method with a cross-sectional approach.

Methods. Analytical observational research with cross-sectional quantification method . A total of 48 subjects with coronary heart disease were examined for serum HDL levels and RDW values as well as coronary angiography examination. The severity of coronary artery stenosis was assessed by this gensini score which was then analyzed statistically

Results. Of the 48 patients with patient characteristics, 36 were male (75%), and 12 female (25%) were obtained. From laboratory examination, it was found that the mean HDL level was 41.68 with a standard deviation of 16.85 and the mean RDW value of the patients was 12.85 with a standard deviation of 0.86. The difference in HDL levels with the severity of CHD was associated with this gensini score, the value of p = 0.001 was obtained. By using the Spearman correlation, it was found that the correlation between HDL levels and this gensini score was p = 0.002 with a value of r = -0.427. With the unpaired T test assessing the difference in RDW value with the severity of CHD associated with this gensini score, the value of p = 0.20 was obtained. By using the Pearson correlation, the correlation between the RDW value and the gensini score is p = 0.06 with a value of r = 0.27.

Conclusion. From the research results , it is concluded that there is a significant relationship between HDL levels and there is no significant relationship between the RDW value and the degree of coronary severity in people with coronary heart disease.