THE RELATIONSHIP OF HIGH SENSITIVE C-REACTIVE PROTEIN AND PLASMA TRIIODOTIRONINE IN END STAGE RENAL DISEASE WITH NON THYROIDAL ILLNESS SYNDROME

Abstract

Background: End stage renal disease (ESRD), with or without dialysis, is a condition with chronic inflammatory state. Chronic kidney disease (CKD) in its course causes alteration in thyroid hormone metabolism, without underlying intrinsic thyroid abnormalities, known as non-thyroid illness syndrome (NTIS). The aim of this study is to determine the relationship between HsCRP levels as a marker of inflammation with plasma T3 levels in ESRD patients, with or without hemodialysis.

Methods: This is a cross sectional study which assessed the relationship between HsCRP levels as a marker of inflammation with plasma T3 levels in ESRD patients, held in Haji Adam Malik General Hospital in Medan. The research sample was chosen consecutively. Patients were taken for venous blood for HsCRP, TSH, T3, fT4, albumin, RFT and for patients undergoing regular hemodialysis (HD), blood samples were taken just before the next HD session.

Results:There is no significant relationship between the etiology of ESRD, both DM and hypertension on HsCRP and T3 levels in both group of patients undergoing hemodialysis and those not undergoing hemodialysis (p> 0.05). Based on statistical analysis, there is no correlation between hemodialysis duration with T3 and HsCRP levels in the group of patients undergoing HD (p>0.05). There is a significant correlation between HsCRP levels and T3 levels in the ESRD group undergoing hemodialysis (R = -0.667; p = 0.001). Conclusion:There is a strong negative correlation between HsCRP levels and plasma T3 levels in ESRD patients both HD and non HD groups.