ASSESSMENT OF GLOBAL LONGITUDINAL STRAIN AS A PREDICTOR OF LESION SIGNIFICANCE IN STABLE CORONARY HEART DISEASE PATIENTS WITH PRESERVED EJECTION FRACTION AT ADAM MALIK HOSPITAL MEDAN

Abstract

Background : Prevalence of coronary heart disease in Indonesia is increasing by age and become the main cause of morbidity and mortality. However, now it has been found that GLS value can reflect the ischemic and infarct area.

Objective : To assessed Global Longitudinal Strain (GLS) as a predictor of lesion significance in stable coronary heart disease patients.

Methods : This research is a cross-sectional study conducted on 28 coronary heart disease patients with preserved EF who underwent coronary angiography examination at Adam Malik Hospital Medan from February 2020 – July 2020. The GLS examination was carried out using speckle tracking software on late diastolic phase. Spearman correlation test was performed to analyze GLS value with coronary angiography results. Bivariate analysis to evaluate GLS value with coronary angiography parameters was carried out with Chi-square and Fisher's Exact test. P value < 0.05 is said to be statistically significant.

Results : After Spearman correlation test, it was found that the correlation coefficient was -0.733, which means that there is a strong relationship between GLS and significant lesions. Calculation of area under the curve (AUC) found value of 0.923 (P = < 0.001, 95% CI 0.885-0.991). The GLS cut off value is -16.4300 with 85,7% sensitivity of 85.7%, 8,6% false positive rate (1-specificity), and 91,4% specificity.

Conclusion : GLS can be used to predict lesions significance in stable coronary heart disease patients and has an inverse relationship with coronary lesions significance.