DIFFERENCES OF FIBRINOGEN LEVELS WITH THE NUMBER OF CORONARY ARTERIAL LESIONS IN PATIENTS OF ACUTE CORONARY SYNDROME

Abstract

Introduction: Coronary heart disease (CHD) is a disease caused by plaque that builds up in the coronary arteries that supplies oxygen to the heart muscle. The main clinical manifestations of CHD and most often causing death is acute coronary syndrome (ACS). The process of atherosclerosis is the most common cause of CHD. Coronary atherosclerosis is a pathological condition of the coronary arteries that results in changes in the structure and function of the arteries as well as a decrease in the volume of blood flow to the heart. Several studies have prospectively reported that fibrinogen is a risk factor for ACS.

Aim: The aim in this study is to know the difference fibrinogen levels between multiple lesion compared with a single lesion group in ACS patients.

Methods: This study is analytic observational with cross sectional design was using secondary data within medical records of ACS patients who underwent coronary angiography and were treated at Haji Adam Malik (HAM) General Hospital from July 2017-July 2019.Data analysis using SPSS 20nd.

Result: Based on bivariate analysis, hypertension and NLR (Neutrophyl Lymphocyte Ratio) were a significant factors for groups of simple and multiple arterial lesions (p = 0.002). This study found that there were differences in mean and standard deviation levels of fibrinogen between simple lesion and the multiple lesion group (178.2 + 34.01 vs. 333.6 ± 117.81, p = 0.000).

Conclusion: There was a significant difference in fibrinogen levels correlate with the number of coronary artery lesions, which is the more higher levels of fibrinogen, the more coronary artery lesions was found in ACS.