DIFFERENCE BETWEEN HSP60 IN POSITIVE AND NEGATIVE H.PYLORI GASTRITIS PATIENTS AND ITS CORRELATION WITH NEUTROPHIL AND LYMPHOCYTE RATIO

Abstract

Background: Gastritis is a disease characterized by an inflammatory process in both the mucosal and submucosal lining of the stomach. Helicobacter pylori (H.pylori) binds to gastric and mucin epithelial cells via HSP60, and the adaptive immune system against HSP60 is induced in patients infected with H. Pylori.

Objective: To determine the comparison of serum HSP60 levels between positive and negative H. pylori gastritis patients and their correlation with neutrophil-lymphocyte ratio. Research

Method: Cross-sectional design. Sampling was carried out at the Endoscopy Unit of Adam Malik General Hospital Medan. The study sample was taken as many as 60 subjects consecutively. The independent variable of the study was H. pylori infection and the dependent variable was HSP60 and neutrophil-lymphocyte ratio. Data analysis used the Mann Whitney U test and the Spearman correlation test.

Results: The demographic characteristics of the study subjects were 36 male subjects (60%), the median value of age 47.7 (25-66) years, the highest educational history was 34 subject high schools (56,7%), the most work history was private employees 24 subject (40%). There was a difference in HSP60 in patients with positive and negative H.pylori gastritis (p <0,000). There was no correlation between HSP60 and neutrophil-lymphocyte ratio in patients with positive and negative H. pylori gastritis (p <0.121).

Conclusion: There are differences in HSP60 in patients with positive and negative H.pylori gastritis.