RELATIONSHIP OF PENTRAXIN 3 LEVELS WITH SEQUENTIAL ORGAN FAILURE ASSESSMENT (SOFA) SCORES IN SEPSIS PATIENTS AT HAJI ADAM MALIK GENERAL HOSPITAL, MEDAN

Abstract

Background Pentraxin3 (PTX3) is an acute phase protein that represents the pentraxin subfamily and is expressed in various cells such as monocytes, endothelia cells, denritic cells and neutrophils during the inflammatory process. The sepsis patients there are dysregulation of the immune mechanism, where monocyte cells and macrophages will be activated which will then secrete proinflammatory cytokines such as TNFα, IL-1, IL-6, IL-8. To assess the severity of the disease based on the degree of organ dysfunction serially each time a score is used, namely Sequential Organ Failure Assessment (SOFA). The aim of this study is to see the relationship of PTX3 levels with SOFA scores in patients with sepsis.

Methods This study is a Prospective cohort study design. After exclusion, there were 30 subject study with clinical criteria for sepsis. PTX3 levels and SOFA score calculations were measured on day 1 and 3, and analyzed by the Spearman correlation test. The differences test between the 2 times groups were analyzed with the Willcoxon statistical test.

Results and Discussion The significant relationship was obtained between PTX3 levels and SOFA scores on the first day (r = 0.779, p = 0.0001) and (r = 0.802, p = 0.0001) and the third day. Respiratory system dysfunction plays a role in increasing PTX3 levels.

Conclusion This study showed the relationship between PTX3 levels with SOFA scores. The increased of PTX3 levels in line with SOFA scores. Both of PTX3 levels on the first day and the third day can be considered as an alternative parameters to evaluate the deterioration of sepsis patients treated at the ICU.