ASSOCIATION OF PLATELET-TO-LYMPHOCYTE RATIO WITH SEVERITY OF CORONARY ARTERY DISEASE IN PATIENTS WITH ACUTE CORONARY SYNDROMES
Keywords:
Atherosklerosis, Acute Coronary Syndrome, SYNTAX score, platelet-lymphocyte ratioAbstract
Background: Coronary artery disease (CAD) is the leading cause of morbidity and mortality throughout the world. It has a complex pathophysiology, and inflammation seems to play an important role in CAD.Platelet lymphocyte ratio (PLR) is a new prognostic marker that integrates the risk prediction of these 2 parameters into 1. It gives an idea about both the aggregation and inflammation pathways, and it may be more valuable than either platelet or lymphocytecount alone in the prediction of coronary atherosclerotic burden.The SYNTAX score (SXscore) is an anatomic scoring system based on coronary angiography (CA) that not only quantifies lesion severity and complexity. The aim of this study was to investigate the association of PLR with the severity of coronary atherosclerosis as assessed by the SXscore in patients with ACS who underwent urgent CA
Methods: Patients were collected from August to December 2019. A cohort prospective study of 60 ACS patients admitted to the emergency department was studied. Variables such as previous comorbidities, laboratory findings and coronary angiography were evaluated. Admission PLR values were calculated before CA was performed. The PLR were divided into 2 groups, 30 patients with PLR < 116 and 30 with PLR > 116. The SXscore was determined from coronary angiography. The patients were divided into 2 groups, those with low SXscores (<23) and those with intermediate to high SXscores (≥23).
Result: A total of 60 patients with ACS who underwent urgent CA were included in the study fromAugust to Desember 2019. From total 60 patients, there were 25 (42 %) patients had SYNTAX score ≥ 23 and 35 (58%) patients had SYNTAX score < 23. There were significant relation difference between both groups. From chi square analysis, there was significant statistic between platelet lymphocyte ratio and SYNTAX Score (OR: 8,7, p value : 0.001).
Conclusions: In conclusion, theplatelet lymphocyte ratio is significantly associated with the severity of coronary atherosclerosis in patients with ACS
