ASSOCIATION BETWEEN VEGF +936 C>T GENE POLYMORPHISM WITH THE DEGREE OF ATROPHY IN GASTRITIS PATIENTS
Keywords:
VEGF polymorphism, VEGF936C>T, degree of atrophy, gastritis.Abstract
In the process of gastritis become its deadly sequel, gastric cancer, some genetic factors are thought to play a role. VEGF is a neoangionesis factor that involved in this process. Some polymorphisms are suspected play a role in determining of its plasma levels. The aim of this study is to analyze the association between VEGF936C>T polymorphism and degree of atrophy in gastritis patient. Atrophy is preliminary lesion before the occurrence of gastric cancer.
Methods: This crossectional study included gastritis patient in Permata Bunda Hospital. Endoscopy was performed to assess the gastric mucosae and the tissue biopsy was taken. VEGF936C>T was examined by Polymerase Chain Reaction (PCR).
Results: Among sixty gastritis patients that included in this study, 23.4% shows atrophy. There is a significant relationship between VEGF 936C>T polymorphism and the degree of atrophy. A significant association is also found between CC genotype and allele C and degree of atrophy (p<0.05).
Conclusion: There is a significant relationship between VEGF 936C>T polymorphism with the degree of atrophy.
