CORRELATION OF PENTRAXIN-3 LEVELS WITH GENSINI SCORE IN ACUTE CORONARY SYNDROME

Abstract

Background: Acute coronary syndrome (ACS) continues to be a major cause of morbidity and mortality throughout the world. Inflammation plays an important role at every stage of development of atherosclerosis. Pentraxin3 (PTX3) is the newly identified acute phase reactant, PTX3 Proteins are expressed in vascular endothelial cells and macrophages. Thus, the level can reflect the presence of blood vessel inflammation. The severity of coronary artery stenosis can be calculated through Gensini score through coronary angiongraphy.

Aim :Find out the relationship of pentraxin 3 levels with Gensini scores in acute coronary syndrome

Methods: Sampling was carried out during june - July 2019. The total population of the study included 61 people suffering from ACS. The entire population was examined by Pentraxin 3 and calculated the severity of coronary artery stenosis with Gensini score through angiography. The study was conducted after obtaining ethical approval and informed consent.

Result And Discussion: Pentraxin 3 levels were obtained with median value of 0.59 (0.06-22.96). The Gensini score was obtained with median value of 62.00 ( 2.00 – 113.00). The Spearman Rank Test, there was no significant relationship between the Pentraxin 3 levels and the Gensini score r = 0,250 dan p = 0,052 .

Conclusion and Suggestion: There was no significant relationship between the Pentraxin 3 levels and the Gensini score. Further research needs to be done by considering the sampling time for the PTX-3 examination given the variation in the time of the attack when coming to the hospital between study subjects so that more stringent patient detection is needed.